NGS Senior Data Scientist

Working closely with Sarepta’s Research and Development groups, the Genomics and Data Science group plays a key role in the discovery, validation, and development of novel precision genetic therapeutics. We are seeking a next-generation sequencing (NGS) Senior Data Scientist to support the design and analysis of high-throughput DNAseq and RNAseq experiments. The NGS Senior Data Scientist will play a critical role in the design and execution of large-scale RNAseq experiments to monitor the impact of therapeutics on muscle health and immune state. The candidate should have human genetics expertise to enable him or her to make informed decisions regarding clinical trial design and interpretation of safety and efficacy data. The candidate must be able communicate and collaborate effectively with diverse stakeholders across the organization. The ideal candidate is a self-motivated, independent thinker who wants to work as part of a collaborative team to bring life-changing medicines to patients in need.

Primary Responsibilities Include:

• Works closely with clinical colleagues to inform clinical trial design and interpretation.
• Works closely with wet lab scientists to develop robust experimental strategies leveraging NGS technologies.
• Designs and executes bioinformatic and biostatistical analyses of data from high-throughput NGS-based sequencing experiments.
• Works collaboratively with project leads to develop optimal experimental strategies, performing in silico predictions and data analysis.
• Researches and evaluates new experimental and computational methods and technologies for continual process improvement.
• Provides synopses of analyses with presentations and written reports.
• Follows scientific direction to execute and meet project timelines and deliverables, collaborating with internal and external stakeholders to ensure project success.
• Performs other related duties as assigned.

Education and Skills Requirements:

• PhD with 0-6 years of postdoctoral and/or industry experience in human genetics, bioinformatics, or related discipline with applied NGS experience.
• Proficiency in data processing, bioinformatics tools, statistics and programming including UNIX/Linux-based environments, shell scripting, python, and R.
• Basic understanding of chemistry, biology, and genetics.
• Excellent organization and communication skills and ability to collaborate effectively.
• Ability to work on multiple projects simultaneously with the flexibility to accommodate changing priorities and deadlines; ability to work independently as well as within multi-disciplinary project teams.
• Experience with Docker, git or related version control software, cloud computing (ideally Amazon Web Services), software packages for machine learning and statistics preferred.
• Experience implementing computational models of on/off target effects of gRNA and analyzing NGS data is preferred.
• Wet-lab experience in or classroom knowledge of molecular biology and gene therapy is preferred.
• Recognized by former peers, colleagues, managers and direct reports for attributes congruent with Sarepta Values: Drive, Excellence, Resilience, Teamwork, Innovation and Compassion.
• Position can be remote-based.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.